Functions Of Liver

The liver is idea to live on responsible for upwards to 500 functions. Some are mentioned below:

1. Blood supply: The liver receives blood render from the hepatic portal vein in addition to hepatic arteries. The hepatic portal vein delivers unopen to 75% of the liver's blood supply, in addition to carries venous blood drained from the spleen, gastrointestinal tract, in addition to its associated organs. The hepatic arteries render arterial blood to the liver, accounting for the remaining quarter of its blood flow. 
2. Storage of large quantity of blood: During emergency province of affairs such every bit blood loss, the hepatic sinusoids contract sending stored blood into circulation.
3. Destruction of haemoglobin: Destruction of haemoglobin forms pigments such every bit bilirubin.
4. Production of Bile: Bile is a digestive juice produced past times liver. It is carried through hepatic ducts in addition to is temporarily stored  in gall bladder. The cystic duct from the gallbladder joins amongst the common hepatic duct to degree the common bile duct. Bile either drains direct into the duodenum via the mutual bile duct, or is temporarily stored inwards the gallbladder via the cystic duct. 
5. Chief site of metabolism of protein, carbohydrates in addition to fats: It involves the breakdown in addition to synthesis of glucose, amino acids, obese acids, glycerol in addition to inter-conversion of carbohydrates, poly peptide in addition to fats.
6. Synthesis in addition to storage of Glycogen: The liver synthesizes in addition to stores unopen to 100 g of glycogen via glycogenesis, the formation of glycogen from glucose. When needed, the liver releases glucose into the blood past times performing glycogenolysis, the breakdown of glycogen into glucose. 
7. Gluconeogenesis: It is the synthesis of glucose from sure enough amino acids, lactate or glycerol. Adipose in addition to liver cells create glycerol past times breakdown of fat, which the liver uses for gluconeogenesis.
8. Production of clotting factors: Some of the proteins synthesized past times the liver include coagulation factors I (fibrinogen), II (prothrombin), V, VII, VIII, IX, X, XI, XIII, likewise every bit protein C, protein S and antithrombin. 
9. Synthesis of substances heparin: It prevents blood clotting
10. Production of Red Blood Cells: In the have trimester fetus, the liver is the master copy site of red blood cell production. By the 32nd calendar week of gestation, the bone marrow has close completely taken over that task. 
11. Production for thrombopoietin: It is a glycoprotein hormone that regulates the production of platelets past times the bone marrow.
12. Lipid metabolism: It performs cholesterol synthesis, lipogenesis, the production of triglycerides, in addition to a volume of the body's lipoproteins are synthesized inwards the liver.
13. Role inwards digestion: It produces in addition to excretes bile (a yellowish liquid) required for emulsifying fats in addition to assistance the absorption of vitamin K from the diet. Some of the bile drains direct into the duodenum, in addition to some is stored inwards the gallbladder.
14. Production of insulin-like increment constituent 1 (IGF-1): It is a polypeptide protein hormone that plays an of import role inwards childhood increment in addition to continues to conduct hold anabolic effects inwards adults.
15. Breakdown of insulin in addition to other hormones. 
16. Breakdown of bilirubin via glucuronidation, facilitating its excretion into bile. 
17. Breakdown in addition to excretion of many waste materials products. 
18. Breakdown or change of toxic substances (e.g., methylation) in addition to most medicinal products inwards a procedure called drug metabolism. This sometimes results inwards toxication, when the metabolite is to a greater extent than toxic than its precursor. Preferably, the toxins are conjugated to avail excretion inwards bile or urine. 
19. Breakdown of ammonia into urea every bit constituent of the urea cycle, in addition to the urea is excreted inwards the urine.
20. Storage of many substances: Examples: glucose (in the degree of glycogen), vitamin A (1–2 years' supply), vitamin D (1–4 months' supply), vitamin B12 (1–3 years' supply), vitamin K, iron, in addition to copper.
21. Immunological effects: The mononuclear phagocyte system of the liver contains many immunologically active cells, acting every bit a 'sieve' for antigens carried to it via the portal system.
22. Production of albumin: It is the most abundant poly peptide inwards blood serum. It is essential inwards the maintenance of osmotic pressure, in addition to acts every bit a carry for fatty acids in addition to steroid hormones.
23. Synthesis of angiotensinogen: It is a hormone responsible for raising the blood pressure when activated past times renin. Renin is an enzyme released when the kidney senses low blood pressure.
24. Generation of oestrus to keep trunk temperature.